The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small animal models that mimick human disease. Now, a group of scientists at Hamburg’s Heinrich Pette Institute headed by Dr. César Muñoz-Fontela succeeded in generating a small animal model with human components for the development of EVD therapies. Their model showed that mice transplanted with human hematopoetic stem cells reproduce typical features of EVD. Infection with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of hemorrhage, and high lethality.
Veröffentlichung: Ebola virus disease in mice transplanted with human hematopoietic stem cells. J Virol. 2015 Feb 11. pii: JVI.03546-14.